医学研究中心
张慧东
职称:研究员
科室:医学研究中心
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简介

张慧东,中山大学全国十大赌博官网研究员,博士生导师,医学研究中心副主任(主持工作)先后曾获得/入选中组部千人计划青年项目、基金委优秀青年科学基金、辽宁省科技奖励一等奖、中国毒理学会优秀青年科技奖、四川省卫计委领军人才、四川省千人计划、四川大学优秀青年科技奖、四川大学青年科技人才奖、四川省卫生健康委学术技术带头人、四川省专家评议(审)委员会、四川省学术技术带头人、中山大学百人计划等。

以环境和女性生殖健康为研究方向,主要从事非编码RNA在环境有害因素导致女性滋养层细胞功能障碍而引发流产中的作用和调控机制研究,先后获得自然科学基金面上项目优秀青年科学基金国家科技部重点专项、千人计划等12项基金的资助,以第一或通讯作者在Proc Natl Acad SciNucleic Acids ResJ Biol ChemSci Total EnvironCell Biol Toxicol等国际知名杂志上发表SCI论文56篇,中科院一区14篇,二区21篇,IF ≥103篇,≥521篇,被ScienceNat CommunAnn Rev BiochemProc Natl Acad Sci等国际知名杂志引用1473次(至2021.03.08)。受邀Chem CommunCell CycleJ Biol Chem等国际知名期刊上写专题和封面文章6篇。受《环境和职业医学》邀请,组织并撰写环境和女性生殖健康专刊;受Springer Nature出版社邀请,撰写关于DNA损伤的Briefs以主编出版“Environment and Female Reproductive Health”英文书籍(PubMed收录,IF: 2.450)。International Conference on Biomedical and Environmental Sciences & Technology全国环境和健康学术会议、全国毒理学大会等国际或国内会议上,多次做受邀或主旨报告。

担任国家基金委自然科学基金、国家科技部重点研发计划重点专项国家科技奖励的评审专家;担任波兰国家科学中心和重庆市、四川省、江苏省、河北省、广东省和贵州省科技项目评审专家;担任广东省科学技术奖评审专家;担任教育部学位与研究生教育发展中心学科评估专家;担任高等学校科学研究优秀成果奖(科学技术)、教育部学位中心博士硕士学位论文、国家留学基金委公派研究生项目评审专家。担任中华预防医学会卫生毒理学专委会、中国诱变剂学会青年委员会、中国康复医学会生殖健康专业委员会、中华预防医学会卫生检验委员会、中国生物化学和分子生物学酶学委员会15个国家一级或二级专委会的委员或常务委员。担任《环境与职业医学》常务编委。担任Nucleic Acids ResSci Total EnvironToxicol Sci16国际知名杂志的审稿人。

近五年2016-2021,围绕非编码RNA在环境有害因素导致女性滋养层细胞功能障碍并引发流产中的作用和调控机制,以第一或通讯作者在Nucleic Acids Res (IF: 11.147)J Biol Chem (Nature Index, IF: 4.106)Environ Pollut (IF: 6.792)Mutat Res Rev (IF: 6.081)Cell Biol Toxicol (IF: 6.284)等本领域核心期刊上发表SCI论文38篇,中科院一区9篇,二区11篇,IF≥102篇,≥511篇。受邀为《环境和职业医学》组织并撰写环境和女性生殖健康专刊4篇;受邀以主编出版“Environment and Female Reproductive Health”英文书籍(Springer Nature出版社)。

联系方式:zhanghd29@mail.sysu.edu.cn

广东省深圳市福田区福明路18 全国十大赌博官网医技楼308,广东 深圳,518033,中国

研究方向:

主要进行女性生殖健康领域的研究,针对临床上的多种女性生殖疾病,例如流产、宫内生长受限、子痫等多种疾病,揭示非编码RNA在环境有害因素导致女性滋养层细胞功能障碍而引发流产中的作用和调控机制,探究女性生殖疾病的发病的原因和内在分子机制,并寻求在临床上预防或治疗疾病的新途径。

主持的项目:

1.       国家自然科学基金面上项目(项目批准号:82073589):项目名称:新lncRNA20273及其m6A修饰在BPDE通过MXD1/eIF4E通路抑制女性滋养层细胞增殖而引发流产中的作用和调控机制,2021.01-2024.12,直接经费56万元,主持。

2.       2017年度国家科技部重点专项(项目批准号:2017YFC1002002):项目名称:人类生育力下降机制和防护保存新策略研究,2017.05-2020.12124.46万元,项目骨干。

3.       国家自然科学基金优秀青年科学基金(项目批准号:81422041):项目名称:分子毒理学,2015.1-2017.12100万元,主持。

4.       国家自然科学基金面上项目(项目批准号:31370793):项目名称:噬菌体T7ssDNA结合蛋白(gp2.5)DNA合成和杂交中新功能和机理的研究,2014.1-2017.1280万元,主持。

代表性论文:

2021

75. An up-regulated lnc-HZ07 inhibits trophoblast cell migration by inactivating PI3K/AKT/MMP2 signaling pathway in Recurrent Pregnancy Loss.  Yang Ye#, Sushi Jiang#, Chenyang Mi, Tao Du, Tingting Liang, Huan Zhong, Jiayu Xie, Wenming Xu, Huidong Zhang*, and Xiaomiao Zhao*.  Reprod. Sci., 2021, In press.  (1933-7205; https://doi.org/10.1007/s43032-021-00630-2; Obstetrics & Gynecology Q3; IF: 2.616; )

74. Environment and Female Reproductive Health, Advances in Experimental Medicine and Biology 1300, Editor, Springer Nature. 2021. (ISSN 0065-2598; https://doi.org/10.1007/978-981-33-4187-6; IF: 2.450)

73. DNA Polymerase Gp90 Activities and Regulations on Strand Displacement DNA Synthesis Revealed at Single-molecule Level.  Shuming Zhang, Xue Xiao, Jingwei Kong, Ke Lu, Shuo-Xing Dou, Peng-Ye Wang, Lu Ma, Yuru Liu, Guohong Li, Wei Li* and Huidong Zhang*.  FASEB J. 2021, 35, e21607. (; DOI: 10.1096/fj.202100033RR; Biology Q1; IF: 5.394)  

72. Up-regulated lnc-HZ02 and miR-hz02 inhibited migration and invasion by down-regulating FAK/SRC/PI3K/AKT pathway in BPDE-treated trophoblast cells.  Jiarong Guo#, Rui Li#, Zhongyan Xu#, Peng Tian, Rong Wang, Youzhu Li, Xia Qiu, Peng Zou, Mei He, Lin Ao*, Qicai Liu*, and Huidong Zhang*. J. Biochem. Mol. Toxicol. 2021, In press. (DOI: https://doi.org/10.1002/jbt.22757; Toxicology Q3; IF: 3.606)

71. Lnc-HZ08 regulates BPDE-induced trophoblast cell dysfunctionsby promoting PI3K ubiquitin degradation and is assciated with miscarriage.  Jiayu Xie#, Tingting Liang#, Jingsong Zhao, Zhongyan Xu, Peng Tian, Rong Wang, Chenyang Mi, Wenxin Huang, Weina Chen, Huidong Zhang*. Cell Biol. Toxicol. 2021, In press.  (0742-2091; Doi.org/10.1007/s10565-021-09606-z; Q1; IF: 6.284)

70. Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01/MXD1 positive feedback loop.  Zhongyan Xu#, Peng Tian#, Jiarong Guo, Chenyang Mi, Tingting Liang, Jiayu Xie, Wenxin Huang, Mengyuan Dai, Weina Chen, and Huidong Zhang*.  Sci. Total Environ. 2021, 776, 145950.  (0048-9697; DOI: https://doi.org/10.1016/j.scitotenv.2021.145950; Q1; IF: 6.551; Cited xx times)

69. LncRNA HOTAIR促进女性滋养层细胞迁移的机制。许仲妍,郭佳蓉,田鹏,邓思思,张慧东*。现代预防医学,2021481272-1276

68. MiR-184促进滋养层细胞凋亡而引起复发性流产的研究。梁婷婷,赵靖嵩,马成龙,杨阳,武雅婷,谢嘉渝,张慧东*现代预防医学,2021481123-1127

67. LncRNA NEAT1抑制女性滋养层细胞增殖的研究。谢嘉渝,马成龙,赵靖嵩,武雅婷,杨阳,梁婷婷,张慧东*。现代预防医学,202148911-915

66. Novel lnc-HZ03 and miR-hz03 promote BPDE-induced human trophoblast cell apoptosis and induce miscarriage by upregulating p53/SAT1 pathway.  Tingting Liang#, Jiayu Xie#, Jingsong Zhao, Wenxin Huang, Zhongyan Xu, Peng Tian, Chenyang Mi, Mengyuan Dai, Shuming Zhang, and Huidong Zhang*. Cell Biol. Toxicol. 2021, In press.  (0742-2091; DOIhttps://doi.org/10.1007/s10565-021-09583-3; Q1; IF: 6.284). 

2020

65. Predicting the animal susceptibility and drugs to SARS-CoV-2 based on Spike glycoprotein combined with ACE2.  Min Shen, Chao Liu, Run Xu, Zijing Ruan, Shiying Zhao, Huidong Zhang, Wang Wen, Xinhe Huang, Li Yang, Yong Tang, Tai Yang, Xu Jia*.  Frontiers in Genetics, section Computational Genomics.  2020, In Press. DOI.org/10.3389/fgene.2020.575012. Cited 1 times

64. Environmental Pollutant Benzo[a]pyrene Induces Recurrent Pregnancy Loss through Promoting Apoptosis and Suppressing Migration of Extravillous Trophoblast. Yang Ye, Sushi Jiang, Chao Zhang, Tao Du, Huan Zhong, Wenming Xu, Huidong Zhang* and Xiaomiao Zhao*. BioMed Res. Int. 2020, In Press. DOI: doi.org/10.1155/2020/8983494. (2314-6133, IF: 2.276; Cited 0 times; Biochemistry & Molecular Biology Q2)

63. Mechanisms of mutagenesis induced by DNA lesions: multiple factors affect mutations in translesion DNA synthesis. Huidong Zhang*. Crit. Rev. Biochem. Mol. Biol., 55: 219-251, 2020. DOI: 10.1080/10409238.2020.1768205.(1040-9238, IF: 7.634; Cited 0 times; Biochemistry & Molecular Biology Q2)

62. Dynamic structural insights into the molecular mechanism of DNA unwinding by the bacteriophage T7 helicase. Jianbing Ma#, Ze Chen#, Chunhua Xu#, Xingyuan Huang, Qi Jia,Zhenyu Zou, Chenyang Mi,Dongfei Ma, Ying Lu*, Huidong Zhang*, and Ming Li*. Nucleic Acids Res., 48: 3156-3164, 2020. DOI: 10.1093/nar/gkaa057.(0305-1048, IF: 11.561; Cited 2 times; Biology Q1)

61. Strand-displacement DNA synthesis by DNA polymerase gp90 exo- of Pseudomonas aeruginosa phage 1. Chenyang Mi#, Shuming Zhang#, Wenxin Huang, Mengyuan Dai, Zili Chai, Wang Yang, Shanshan Deng, Lin Ao*, and Huidong Zhang*.Biochimie,170: 73-87, 2020. DOI: 10.1016/j.biochi.2019.12.013. (0300-9084, IF: 3.362; Cited 0 times; Biochemistry & Molecular Biology Q3)

60. Epigenetically modified N6-methyladesine inhibits DNA replication by human DNA Polymerase iota. Shuming Zhang, Bianbian Li, Ke Du, Tingting Liang, Mengyuan Dai, Wenxin Huang, Huizhi Zhang, Yihui Ling, and Huidong Zhang*. Biochimie, 168: 134-143, 2020. DOI: 10.1016/j.biochi.2019.10.018 (0300-9084, IF: 3.362; Cited 3 times; Biochemistry & Molecular Biology Q3)

2019

59. Epigenetic DNA Modification N6-methyladenine inhibits DNA replication bySulfolobus solfataricus Y-family DNA Polymerase Dpo4. Ke Du, Shuming Zhang, Weina Chen, Mengyuan Dai, Zhongyan Xu, Tingting Liang, Wenxin Huang, Yihui Ling, and Huidong Zhang*. Arch. Biochem. Biophys., 675: 108-120, 2019. DOI: 10.1016/j.abb.2019.108120. (0003-9861, IF: 3.559; Cited 2 times; Biochemistry & Molecular Biology Q3)

58. Ribonucleoside Triphosphates Promote T7 DNA Replication and the Lysis of T7-Infected Escherichia coli. Zhenyu Zou, Wendi Xu, Chenyang Mi, Ying Xu, Ke Du, Bianbian Li, Yang Ye, Yihui Ling, and Huidong Zhang*. Biochimie, 167: 25-33, 2019. DOI: 10.1016/j.biochi.2019.09.002. (0300-9084, IF: 3.362; Cited 1 times; Biochemistry & Molecular Biology Q3)

57. Protein Interactions in T7 DNA Replisome Inhibit the Bypass of Abasic Site by DNA polymerase. Zhenyu Zou, Tingting Liang, Zhongyan Xu, Jiayu Xie, Shuming Zhang, Weina Chen, Siqi Wan, Yihui Ling, and Huidong Zhang*. Mutagenesis, 34: 355-361, 2019. DOI:10.1093/mutage/gez013.(IF: 2.898; Cited 1 times; Biology Q3).

56. Epigenetic DNA modification N6-methylAdesine inhibits DNA replication by DNA Polymerase ofPseudomonas aeruginosa Phage PaP1. Bianbian Li, Ke Du, Shiling Gu, Jiayu Xie, Tingting Liang,Zhongyan Xu, Hui Gao,Yihui Ling, Shuguang Lu, Zhen Sun*, and Huidong Zhang*. Chem. Res. Toxicol., 32: 840-849, 2019. DOI: 10.1021/acs.chemrestox.8b00348. (0893-228X, IF: 3.278; Cited 4 times; Toxicology Q2)

55. Epigenetically modified N6-methylAdesine inhibits DNA replication by human DNA Polymerase eta. Ke Du#, Xiangqian Zhang#, Zhenyu Zou, Bianbian Li, Shiling Gu, Shuming Zhang, Xiaoyi Qu, Yihui Ling, and Huidong Zhang*. DNA Repair, 2019, 78, 81-90. DOI: 10.1016/j.dnarep.2019.03.015. (1568-7864, IF: 4.461; Cited 6 times; Toxicology Q2)

54. lncRNA在女性生殖系统恶性肿瘤中的功能和作用机制。梁婷婷,米辰炀,谢嘉渝,许仲妍,杨舒,张慧东*。环境与职业医学,2019, 36, 243-249.(应邀专刊:环境和女性生殖健康)。

53. RNAm6A修饰在女性生殖健康中的作用和机制。许仲妍#,谢嘉渝#,田震,梁婷婷,陈维娜,李雪莹,王瑜阳,张慧东*。环境与职业医学,2019, 36, 226-231.(应邀专刊:环境和女性生殖健康)。

52. 多环芳烃暴露致女性生殖毒性及其分子机制。米辰炀,许仲妍,谢嘉渝,陈维娜,李雪莹,方鑫*,张慧东*。环境与职业医学,2019, 36, 43-49.(应邀专刊:环境和女性生殖健康)。

51. "环境与女性生殖健康"专栏之序。张慧东。环境与职业医学,2019, 36, 33-34.(应邀专刊:环境和女性生殖健康,专刊组稿负责人)。

2018

50. Egg yolk immunoglobulins supplementation prevents rat liver from aflatoxin B1-induced oxidative damage and genotoxicity. Taotao Qiu, Xing Shen, Xiangmei Li, Yunyun Gong, Zhongmin Zou, Chunhong Liu, Feng Ye, Chenyang Mi, Zhenlin Xu, Yuanming Sun, Jie Lin, Huidong Zhang*, and Hongtao Lei*. J. Agric. Food Chem., 66: 13260-13267, 2018. DOI: 10.1021/acs.jafc.8b04659. (0021-8561, IF: 3.571; Cited 2 times; Agriculture Q1).

49. Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast Swan71 cells due to the inhibited filopodia formation and down-regulated PI3K/AKT/CDC42/PAK1 pathway mediated by the increased miR-194-3p. Zhen Tian#, Rong Wang#, Xi Zhang, Bin Deng, Chenyang Mi, Tingting Liang, Yihui Ling, Hongli Li, and Huidong Zhang*. Toxicol. Sci., 166: 25-38, 2018. DOI: 10.1093/toxsci/kfy182. (1096-6080, IF: 4.181; Cited 8 times; Medicine Q2)

48. Protein Interactions in T7 DNA Replisome Facilitate DNA Damage Bypass. Zhenyu Zou#, Ze Chen#, Qizhen Xue, Ying Xu, Jingyuan Xiong, Ping Yang, Shuai Le*, and Huidong Zhang*. ChemBioChem, 19, 1740-1749, 2018. DOI: 10.1002/cbic.201800203. (1439-4227, IF: 2.847; Cited 4 times; BiologyQ3)

47. Consecutive Ribonucleoside Monophosphates on Template Inhibit DNA Replication by T7 DNA Polymerase or by T7 Polymerase and Helicase Complex. Zhenyu Zou, Ze Chen, Yin Cai, Huang Yang, Ke Du, Bianbian Li, Yiguo Jiang, and Huidong Zhang*. Biochimie, 151: 128-138, 2018. https://doi.org/10.1016/j.biochi.2018.05.022. (0300-9084, IF: 3.362; Cited 5 times; Biochemistry & Molecular Biology Q3)

46. 单分子技术研究T7解旋酶解旋和换链。陈泽,马建兵,贾棋,黄星榞,徐春华,张慧东*,陆颖*。物理学报(Acta Physica Sinica), 2018, 67, 118103.

45. Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation. Mengyu Shen#, Huidong Zhang#, Shen Wei,Zhenyu Zou, Shuguang Lu, Gang Li,Xuesong He, Melissa Agnello, Wenyuan Shi*, Fuquan Hu*, and Shuai Le*. Nucleic Acids Res., 46: 4505-4514, 2018. DOI: 10.1093/nar/gky160. (0305-1048, IF: 11.561; Cited 10 times; Biology Q1)

44. General misincorporation frequency: re-evaluation of the fidelity of DNA polymerases. Jie Yang, Bianbian Li, Xiaoying Liu, Hong Tang, Xiyao Zhuang, Mingqi Yang, Ying Xu, Huidong Zhang*, and Chun Yang*. Biochem. Biophys. Res. Commun., 496: 1076-1081, 2018. DOI: https://doi.org/10.1016/j.bbrc.2018.01.135. (0006-291X, IF: 2.705; Cited 3 times; Biology Q3)

43. IgY reduces AFB1-induced cytotoxicity, cellular dysfunction, and genotoxicity in human L-02 hepatocytes and Swan 71 trophoblasts. Taotao Qiu, Xing Shen, Zhen Tian, Riming Huang, Xiangmei Li, Juan Wang, Rong Wang, Yuanming Sun, Yiguo Jiang, Hongtao Lei* and Huidong Zhang*. J. Agric. Food Chem., 66: 1543-1550, 2018. DOI: 10.1021/acs.jafc.7b05385. (0021-8561, IF: 3.571; Cited 8 times; Agriculture Q1)

42. Single-stranded DNA hybridization facilitated by T7 single-stranded DNA binding protein (gp2.5) rapidly initiates from the strandterminus or internally followed by a slow zippering step. Zhenyu Zou#, Siying Wu#, Jingyuan Xiong, Huangyuan Li, Yiguo Jiang, and Huidong Zhang*. Biochimie, 147: 1-12, 2018. DOI: 10.1016/j.biochi.2017.12.012. (0300-9084, IF: 3.362; Cited 4 times; Biochemistry & Molecular Biology Q3)

41. Bypass of an abasic site via the A-rule by DNA polymerase of Pseudomonas aeruginosa phage PaP1. Xiaoying Liu, Xiaoli Zou, Huangyuan Li, Zhenyu Zou, Jie Yang, Chenlun Wang,Shunhua Wu*, and Huidong Zhang*. Chem. Res. Toxicol.,31: 58-65, 2018. DOI: 10.1021/acs.chemrestox.7b00287. (0893-228X, IF: 3.278; Cited 7 times; Toxicology Q2)

2017

40. Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide induces human trophoblast Swan 71 cells dysfunctions due to cell apoptosis through disorder of mitochondrial fission/fusion. Weiping Wang, Rong Wang, Qiao Zhang, Gil Mor, and Huidong Zhang*. Environ. Pollut., 233: 820-832, 2017.DOI: 10.1016/j.envpol.2017.11.022. (0269-7491, IF: 6.792; Cited 14 times; Environmental science Q2)

39. ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway. Juntang Yang#, Fei Han#, Wenbin Liu, Hongqiang Chen, Xianglin Hao, Xiao jiang, Li Yin, Yongsheng Huang, Jia Cao, Huidong Zhang, and Jinyi Liu*. J. Exp. Clin. Cancer Res., 36: 170, 2017. DOI: 10.1186/s13046-017-0643-9. (1756-9966; IF: 5.646; Cited 10 times; Oncology Q2)

38. LHX6, an independent prognostic factor, inhibits lung adenocarcinoma progression through transcriptional silencing of β-catenin. Juntang Yang, Fei Han, Wenbin Liu, Mingqian Zhang, Yongsheng Huang, Xianglin Hao, Xiao Jiang, Li Yin, Hongqiang Chen, Jia Cao, Huidong Zhang* and Jinyi Liu*. J. Cancer, 8: 2561-2574, 2017. DOI: 10.7150/jca.19972. (1837-9664, IF: 3.249; Cited 7 times; Oncology Q3)

37. Error-prone bypass of O6-methylguanine by DNA polymerase of Pseudomonas aeruginosa phage PaP1. Shiling Gu#, Jingyuan Xiong#, Ying Shi, Jia You,Zhenyu Zou, Xiaoying Liu, and Huidong Zhang*. DNA Repair, 57: 35-44, 2017. DOI: http://dx.doi.org/10.1016/j.dnarep.2017.06.021. (1568-7864, IF: 4.461; Cited 14 times; Toxicology Q2)

36. Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast HTR-8/SVneo cells by down-regulating MMP2 through inhibition of FAK/SRC/PI3K/AKT/eNOS pathway. Rong Wang, Weiping Wang, Lin Ao, Zi Wang, Xianglin Hao, and Huidong Zhang*. Toxicology, 386: 72-83, 2017. DOI: http://dx.doi.org/10.1016/j.tox.2017.05.008. (0300-483X, IF: 3.817; Cited 21 times; Toxicology Q2)

35. Error-free bypass of 7,8-dihydro-8-oxo-2’-deoxyguanosine by DNA polymerase of Pseudomonas aeruginosa phage PaP1. Shiling Gu, Qizhen Xue, Qin Liu, Mei Xiong, Wanneng Wang*, and Huidong Zhang*. Genes, 8: 18, 2017. DOI: 10.3390/genes8010018. (2073-4425; Invited; IF: 3.331; Cited 15 times; Genetics & Heredity Q2)

34. Low-concentration serum promotes the adhesion andspreading of mouse fibroblast L929 cell onhydrophobic glass surface. Weiping Wang#, Rong Wang#,Peng Qin#, Huan Yang, Changguo Ma, Fan Zhang, Qiao Zhang*, Yuehua Cui*, and HuidongZhang*.J. Biomater. Tissue Eng., 7: 333-342, 2017. DOI: https://doi.org/10.1166/jbt.2017.1572. (2157-9083; IF: 2.066; Cited 3 times; Cell & Tissue Engineering Q4)

2016

33. Pseudomonas aeruginosa phage PaP1 DNA polymerase is an A-family high processive DNA polymerase with ssDNA and dsDNA 3¢ to 5¢ exonuclease activity. Binyan Liu, Shiling Gu, Nengsong Liang, Mei Xiong, Qizhen Xue, Shuguang Lu, Fuquan Hu, and Huidong Zhang*. Virus Genes, 52:538-551, 2016. DOI:10.1007/s11262-016-1329-7. (IF: 1.845; Cited 9 times; virus Q4)

32. Kinetic analysis of bypass of O6-methylguanine by the catalytic core of yeast DNA polymerase eta. Binyan Liu#, Qizhen Xue#, Shiling Gu,Weiping Wang, Jie Chen, Yingqing Li, Chunxue Wang, and Huidong Zhang*.Arch. Biochem. Biophys., 596: 99-107, 2016. DOI:10.1016/j.abb.2016.03.009. (0003-9861, IF: 3.559; Cited 16 times; Biochemistry & Molecular Biology Q3)

31. Mechanisms of mutagenesis: DNA replication in the presence of DNA damage.Binyan Liu, Qizhen Xue, Yong Tang, Jia Cao, F. Peter Guengerich, and Huidong Zhang*. Mutat. Res. Rev.,768: 53-67, 2016. DOI:10.1016/j.mrrev.2016.03.006. (1383-5742, IF: 6.213; Cited 35 times; Toxicology Q1)

30. Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2´-deoxyguanosine by the catalytic core of yeast DNA polymerase eta. Qizhen Xue#, Mengyu Zhong#, Binyan Liu, Yong Tang, Zeliang Wei, F. Peter Guengerich, and Huidong Zhang*. Biochimie, 121: 161-169, 2016. DOI:10.1016/j.biochi.2015.12.009. (0300-9084, IF:3.362; Cited 15 times; Biochemistry & Molecular Biology Q3)

29. Binding affinities among helicase, DNA polymerase and replication intermediate DNA in the T7 DNA replisome. Huidong Zhang*,Yong Tang, Seung-Joo Lee, Zeliang Wei, Jia Cao, and Charles C. Richardson*. J. Biol. Chem., 291: 1472-1480, 2016. DOI:10.1074/jbc.M115.698233. (0021-9258, IF:4.573; Cited 19 times; Biology Q2)

2015

28. DNA Replication-Damage from Environmental Carcinogens. Huidong Zhang*. Invited Briefs, Springer Briefs in Biochemistry and Molecular Biolgy, 2015, 1-51. (Invited)

27. Kinetic analysis of bypass of abasic site by the catalytic core of yeast DNA polymerase eta. Juntang Yang#, Rong Wang#, Binyan Liu, Qizhen Xue, Mengyu Zhong, Hao Zeng, and Huidong Zhang*. Mutat. Res.-Fund. Mol. M., 779: 134-143, 2015. DOI: 10.1016/j.mrfmmm.2015.07.001. (0027-5107, IF: 3.680; Cited 14 times; Toxicology Q2)

2014

26. Epigenetic regulation of SOX30 is associated with testis development in mice. Fei Han, Yan Dong, Wenbin Liu, Xuexiang Ma, Ronghui Shi, Hongqiang Chen, Zhihong Cui, Lin Ao, Huidong Zhang, Jia Cao, and Jinyi Liu*. PLoS One, 9(5): e97203, 2014. DOI:10.1371/Journal.pone.0097203. (1932-6203, IF: 3.234; Cited 27 times; Multidisciplinary Sciences Q2)

2012

25. Heterohexamer of 56- and 63-kDa gene 4 helicase-primase of bacteriophage T7 in DNA replication. Huidong Zhang#, Seung-Joo Lee, Arkadiusz W. Kulczyk, Bin Zhu, and Charles C. Richardson*. J. Biol. Chem.,287: 34273-34287, 2012. DOI:10.1074/jbc.M112.401158. (0021-9258, IF: 5.328; Cited 9 times; Biology Q2)

24. The roles of tryptophans in primer synthesis by the DNA primase of bacteriophage T7. Huidong Zhang#, Seung-Joo Lee#, and Charles C. Richardson*. J. Biol. Chem.,287: 23644-23656, 2012.DOI:10.1074/jbc.M112.366096. (0021-9258, IF: 5.328; Cited 8 times; Biology Q2)

2011

23. Essential protein interactionswithin the replisome regulate DNA replication. Huidong Zhang, Seung-Joo Lee, and Charles C. Richardson*. Cell Cycle, 10:3413-3414, 2011. DOI:10.4161/cc.10.20.17523. (1538-4101, Invited feature article; IF: 5.359; Cited 6 times; Cell Biology Q2)

22. Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis. Huidong Zhang#,Seung-Joo Lee#, Bin Zhu, Ngoc Q. Tran, Stanley Tabor, and Charles C. Richardson*. Proc. Natl. Acad. Sci. USA, 108:9372-9377, 2011. DOI:10.1073/pnas.1106678108. (0027-8424, IF: 10.591; Cited 50 times; Multidisciplinary Sciences Q1)

2010

21. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. Huidong Zhang, Urban Bren, Ivan D. Kozekov, Carmelo J. Rizzo, Donald F. Stec, and F. Peter Guengerich*. 238th American-Chemical-Society National Meeting. Washington, DC.AUG 16-20, 2009. Chem. Res. Toxicol., 23: 275-275, 2010. (0893-228X, IF: 4.148; Chemistry, Medicinal Q2)

 

20. Effect of N2-guanyl modifications on early steps in catalysis of polymerization by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W. Huidong Zhang and F. Peter Guengerich*. J. Mol. Biol.,395:1007-1018, 2010.DOI:10.1016/j.jmb.2009.11.071. (0022-2836, IF: 4.008; Cited 29 times; Biochemistry & Molecular Biology Q2)

2009

19. Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation. Huidong Zhang, Jeff W. Beckman, and F. Peter Guengerich*. J. Biol. Chem.,284:35144-35153, 2009. DOI: 10.1074/jbc.M109.067397. (0021-9258, IF: 5.328; Cited 13 times; Biology Q2)

18. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. Huidong Zhang, Urban Bren, Ivan D. Kozekov,Carmelo J. Rizzo, Donald F. Stec, and F. Peter Guengerich*. J. Mol. Biol., 392:251-269, 2009. DOI: 10.1016/j.jmb.2009.07.019. (0022-2836, IF: 4.008; Cited 26 times; Biochemistry & Molecular Biology Q1)

17. Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4. Guanine N2, N2-dimethyl substitution produces inactive and miscoding polymerase complexes. Huidong Zhang#,Robert L. Eoff#, Ivan D. Kozekov, Carmelo J. Rizzo,Martin Egli, and F. Peter Guengerich*. J. Biol. Chem., 284:17687-17699, 2009.DOI: 10.1074/jbc.M109014274. (0021-9258, IF: 5.328; Cited 33 times; Biology Q2)

16. Versatility of Y-family sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkyl guanine adducts. Huidong Zhang#,Robert L. Eoff#, Ivan D. Kozekov, Carmelo J. Rizzo,Martin Egli, and F. Peter Guengerich*. J. Biol. Chem.,284:3563-3576, 2009. DOI: 10.1074/jbc.M807778200. (0021-9258, Cover paper; IF: 5.328; Cited 53 times; Biology Q2)

2008

15. Effect of N2-alkylguanine adducts on replication by Y-class Sulfolobus solfataricus DNA Polymerase Dpo4. Huidong Zhang, Robert L. Eoff, Karen C. Angel, and F. Peter Guengerich*. 236th National Meeting of the American-Chemical-Society. Philadelphia, PA. AUG 17-21, 2008. Chem. Res. Toxicol., 21: 2443, 2008. (0893-228X, IF: 4.148; Cited 1 times; Toxicology Q2)

14. Template enhanced activity of lipase accommodated in siliceous mesocellular foams. Yanmei Zhang, Lifang Zhao, Jun Li, Huidong Zhang, Liangyu Zheng, Shugui Cao*, and Can Li*. Biochem. Biophys. Res. Commun.,372:650-655, 2008. DOI: 10.1016/j.bbrc.2008.05.089. (0006-291X, IF: 3.297; Cited 16 times; Biochemistry & Molecular Biology Q3)

13. Asymmetric hydroformylation of olefins catalyzed by rhodium nanoparticles chirally stabilized with (R)-BINAP ligand. Difei Han, Xiaohong Li, Huidong Zhang, Zhimin Liu, Gengshen Hu, and Can Li*. J. Mol. Catal. A: Chem., 283:15-22, 2008. DOI: 10.1016/j.molcata.2007.12.008. (1381-1169, IF: 3.160; Cited 47 times; Chemistry, Physical Q3)

12. An efficient resolution of racemic secondary alcohols on magnetically separable biocatalyst. Yanmei Zhang, Jun Li, Difei Han, Huidong Zhang, Peng Liu, and Can Li*. Biochem. Biophys. Res. Commun., 365: 609-613, 2008. DOI: 10.1016/j.bbrc.2007.10.205.(0006-291X, IF: 2.297; Cited 44 times; Biochemistry & Molecular BiologyQ3)

2007

11. Kinetic study of the catalytic reforming of CH4 with CO2 to syngas over Ni/ alpha-Al2O3 catalyst: The effect of temperature on the reforming mechanism. Yuehua Cui, Huidong Zhang, Hengyong Xu*, and Wenzhao Li. Appl. Catal. A: Gen., 318:79-88, 2007. DOI: 10.1016/j.apcata.2006.10.044. (0926-860X, IF: 3.942; Cited 79 times; Environmental Sciences Q2)

10. The CO2 reforming of CH4 over Ni/La2O3/alpha-Al2O3 catalysts: The effect of La2O3 contents on the kinetic performance. Yuehua Cui, Huidong Zhang, Hengyong Xu*, and Wenzhao Li. Appl. Catal. A: Gen., 331: 60-69, 2007. DOI: 10.1016/j.apcata.2007.06.039. (0926-860X, IF: 3.942; Cited 69 times; Environmental Sciences Q2)

9. Kinetic depressing the deposition of carbon species on Ni-based catalysts: La2O3 adjusts the reaction rates of CO2 higher than CH4 by tuning the Ea and pre-exponential factor. Yuehua Cui, Huidong Zhang, Hengyong Xu*, Qingjie Ge, Yuzhong Wang, Shoufu Hou, and Wenzhao Li. Stud. Surf. Sci. Catal., 167: 281-286, 2007.  DOI: 10.1016/S0167-2991(07)80145-5 (Cited 4 time)

8. Chiral synthesis on catalysts in nanopores. Can Li*, Huidong Zhang, Dongmei Jiang, and Qihua Yang. Chem. Commun., 6: 547-558, 2007. DOI: 10.1039/b609862b. (1359-7345, Invited feature article; IF: 6.169; Cited 194 times; Chemistry Q1)

2006

7. Heterogeneous asymmetric hydroformylation of olefins on chirally modified Rh/SiO2 catalysts. Difei Han, Xiaohong Li, Huidong Zhang, Zhimin Liu, Jun Li, and Can Li*. J. Catal., 243: 318-328, 2006. DOI: 10.1016/j.jcat.2006.08.003. (0021-9517, IF: 6.201; Cited 65 times; Chemistry, Physical Q1)

6. Asymmetric epoxidation of 6-cyano-2,2-dimethylchromene on Mn(salen) catalyst immobilized in mesoporous materials. Huidong Zhangand Can Li*. Tetrahedron, 62: 6640-6649, 2006. DOI:10.1016/j.tet.2006.01.117. (0040-4020, Invited paper; IF: 3.060; Cited 81 times; Chemistry, Organic Q3)

5. Enantioselective epoxidation of unfunctional olefins catalyzed by the Mn(salen) catalysts immobilized in the nanopores of mesoporous materials. Huidong Zhang,Yanmei Zhang, and Can Li*. J. Catal., 238: 369-381, 2006. DOI: 10.1016/j.jcat.2005.12.023.(0021-9517, IF: 6.201; Cited 130 times; Chemistry, Physical Q1)

2005

4. Asymmetric epoxidation of unfunctional olefins catalyzed by Mn(salen) axially immobilized onto insoluble polymers. Huidong Zhang,Yanmei Zhang, and Can Li*. Tetrahedron: Asymmetry, 16: 2417-2423, 2005. DOI: 10.1016/j.tetasy.2005.05.034. (IF: 2.652; Cited 44 times; Chemistry, Organic Q3)

3. Heterogeneous enantioselective epoxidation catalyzed by Mn(salen) complexes grafted onto mesoporous materials by phenoxyl group. Huidong Zhang, Song Xiang, Jianliang Xiao, and Can Li*. J. Mol. Catal. A: Chem., 238: 175-184, 2005. DOI: 10.1016/j.molcata.2005.05.024. (1381-1169, IF: 3.160; Cited 84 times; Chemistry, Physical Q3)

2. Enantioselective epoxidation of unfunctional olefins catalyzed by Mn(salen) complexes immobilized in porous materials via phenyl sulfonic group. Huidong Zhang,Song Xiang, and Can Li*. Chem. Commun., 1209-1211, 2005. DOI: 10.1039/b417041e. (1359-7345, IF: 6.169; Cited 144 times; Chemistry Q1)

1. The surface sites of sulfated zirconia studied in situ by laser-induced fluorescence spectroscopy. Jun Chen, Zhaochi Feng, Jianying Shi, Pinliang Ying, Huidong Zhang, and Can Li*. Chem. Phys. Lett., 401: 104-108, 2005. DOI: 10.1016/ j.cplett.2004.11.039. (0009-2614, IF: 1.897; Cited 4 times; Physics, Atomic, Molecular & Chemical Q3)